2A,2B-Dihomo-15-alkyl PGF1 α analogs

ABSTRACT

2a,2b-Dihomo-15-methyl and 15-ethyl PGF- and PGE-type compounds are disclosed with process for making them. These compounds are useful for a variety of pharmacological purposes, including anti-ulcer, inhibition of platelet aggregation, increase of nasal patency, labor inducement at term, and wound healing.

The present application is a division of Ser. No. 511,220, filed Oct. 2, 1974, issued on Aug. 10, 1976 as U.S. Pat. No. 3,974,195.

The present invention relates to prostaglandin analogs, the essential material constituting a disclosure of which is incorporated here by reference from U.S. Pat. No. 3,974,195. 

I claim:
 1. An optically active compound of the formula: ##STR1## wherein Z is

    CH.sub.3 OH,

    ch.sub.3 oh,

    ch.sub.2 ch.sub.3 oh,

or

    CH.sub.2 CH.sub.3 OH;

and Wherein R₁ is hydrogen, alkyl of one to 12 carbon atoms, inclusive, ##STR2## OR PHARMACOLOGICALLY ACCEPTABLE SALTS THEREOF WHEN R₁ is hydrogen.
 2. A compound according to claim 1, wherein Z is

    CH.sub.3 OH.


3. 2a,2b-Dihomo-15(S)-15-methyl-PGF₁α, a compound according to claim 2, wherein R₁ is hydrogen.
 4. 2A,2B-Dihomo-15(S)-15-methyl-PGF₁α, methyl ester, a compound according to claim 2, wherein R₁ is methyl.
 5. A compound according to claim 1, wherein Z is

    CH.sub.3 OH.


6. 2a,2b-Dihomo-15(R)-15-methyl-PGF₁α, a compound according to claim 5, wherein R₁ is hydrogen.
 7. 2A,2B-Dihomo-15(R)-15-methyl-PGF₁α, methyl ester, a compound according to claim 40, wherein R₁ is methyl. 